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A total of 408 confirmed strokes occurred in a total of 1.1 million women during 3.6 million woman-years of observation.The incidence of stroke was thus 11.3 per 100,000 women-years.On the basis of data from 295 women with stroke who were interviewed and their controls,the odds ratio for ischemic stroke among current users of oral contraceptives,as compared with former users and women who had never used such drugs,was 1.18(95 percent confidence interval,0.54 to 2.59)after adjustment for other risk factors for stroke.The adjusted odds ratio for hemorrhagic stroke was 1.14(95 percent confidence interval,0.60 to 2.16).With respect to the risk of hemorrhagic stroke,there was a positive interaction between the current use of oral contraceptives and smoking(odds ratio for women with both these factors,3.64;95 percent confidence interval,0.95 to 13.87).Stroke is rare among women of childbearing age.Low-estrogen oral-contraceptive preparations do not appear to increase the risk of stroke. |
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cerebral infarction
cerebrovascular accident
cerebrovascular accident,women
cerebrovascular disease,risk factors in
oral contraceptives
oral contraceptives,cerbrovascular disease and
oral contraceptives,neurologic complications with
risk factors
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